Dovgalev A.M. 2018 Vol. 20 No. 3

OBRABOTKAMETALLOV Vol. 20 No. 3 2018 139 EDITORIAL MATERIALS разработанной автором методики стратегического планирования является предложение перехода к «интерактивному стратегическому менеджменту», который в своей концептуальной основе ори- ентируется на творческий потенциал всего коллектива и изыскание путей его построения на базе оперативного преодоления ускоряющихся изменений, возрастающей организационной сложности и непредсказуемой изменяемости внешнего окружения. Это же авторское резюме на английском языке A considerable part of innovative plans concerning implementation of developments with underlying novelties either do not reach the implementing stage, or in fact yield less benefit than anticipated. One of the reasons of such failures is the fact that the manager lacks real tools for planning, evaluating and controlling innovations. The article brings forward the mechanism for a strategic planning of a company, based on the analysis of both inner company’s resources, and outer competitive strength, as well as on searching ways of using external opportunities with account taken of the company’s specific character. Strategic planning is based on a code of regulations and procedures containing a series of methods, the use of which makes it possible for company’s manager to ensure prompt measures of reaction to outer business environment changes. Such methods include: strategic segmentation; solving problems in real-time mode; diagnostics of strategic readiness to operate in the context of the future; working out a general plan of management; planning of the business position of the firm; strategic transformation of the company. Strategic planning process is presented as a closed cycle consisting of 9 successive stages, each of them represents a logical sequence of measures ensuring the dynamics of system development. The developed by the author strategic planning methods result in the recommendation to proceed to “interactive strategic management” which is conceptually based on the constructive potential of the collective body, on searching ways of its building on the basis of effective overcoming accelerating changes, increasing organizational complexity, and unpredictable changeability of the environment. Пример структурированного авторского резюме из иностранного журнала в Scopus Purpose: Because of the large and continuous energetic requirements of brain function, neurometabolic dysfunction is a key pathophysiologic aspect of the epileptic brain. Additionally, neurometabolic dysfunction has many self-propagating features that are typical of epileptogenic processes, that is, where each occurrence makes the likelihood of further mitochondrial and energetic injury more probable. Thus abnormal neurometabolism may be not only a chronic accompaniment of the epileptic brain, but also a direct contributor to epileptogenesis. Methods:We examine the evidence for neurometabolic dysfunction in epilepsy, integrating human studies of metabolic imaging, electrophysiology, microdialysis, as well as intracranial EEG and neuropathology. Results: As an approach of noninvasive functional imaging, quantitative magnetic resonance spectroscopic imaging (MRSI) measured abnormalities of mitochondrial and energetic dysfunction (via 1H or 31P spectroscopy) are related to several pathophysiologic indices of epileptic dysfunction. With patients undergoing hippocampal resection, intraoperative 13C-glucose turnover studies show a profound decrease in neurotransmitter (glutamate-glutamine) cycling relative to oxidation in the sclerotic hippocampus. Increased extracellular glutamate (which has long been associated with increased seizure likelihood) is significantly linked with declining energetics as measured by 31PMR, as well as with increased EEG measures of Teager energy, further arguing for a direct role of glutamate with hyperexcitability. Discussion: Given the important contribution that metabolic performance makes toward excitability in brain, it is not surprising that numerous aspects of mitochondrial and energetic state link significantly with electrophysiologic and microdialysis measures in human epilepsy. This may be of particular relevance with the self-propagating nature of mitochondrial injury, but may also help define the conditions for which interventions may be developed. © 2008 International League Against Epilepsy.